Publications

AUT00206, a Kv3 channel modulator with potential for the treatment of Fragile X Syndrome
Fragile X conference, 2017

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Causal mutations in the genes encoding Kv3.1 and Kv3.2 have been increasingly linked to debilitating CNS diseases such as epilepsy, developmental encephalopathies, intellectual disability and autism

Gunthorpe,

Nature Communications, 2022

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Kv3 6 offers potential as a precision medicine approach for the treatment of progressive myoclonic epilepsy (EPM7)Modulator AUT0020

Feng et al

Cell Reports Medicine, 2024

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Kv3 Modulator AUT00201 can promote recovery post CNS trauma such as stroke via enhanced activity of parvalbumin interneurones

Okabe et al

Nature Communications, 2025

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Impact of Kv3 Channel Modulator AUT3 on Auditory Temporal Resolution in Rats
ARO Annual Meeting (22-26 February 2014)
Rybal ko et al

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AUT3, a Kv3 channel modulator, counteracts elevation of spontaneous firing rates in the auditory midbrain following noise trauma
Society for Neuroscience Annual Meeting (9-13 November 2013)​
Hesse et al

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AUT3, a Kv3.1 positive modulator, suppresses chronic noise-induced tinnitus in a rat model​
Tinnitus Research Initiative Conference (15-18 May 2013)
Turner et al

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Impact of Kv3 Channel Modulator AUT3 on In Vivo Auditory Processing in Mice
ARO Annual Meeting (16-20 February 2013)
Hesse et al

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Autifony and collaborators publish the results from a clinical trial of AUT00206 in patients with schizophrenia

Kaar SJ, Angelescu I, Nour MM, Marques TR, Sharman A, Sajjala A, Hutchison J, McGuire P, Large C, Howes OD. The effects of AUT00206, a novel Kv3.1/3.2 potassium channel modulator, on task-based reward system activation: a test of mechanism in schizophrenia. Psychopharmacology (Berl). 2022 Oct;239(10):3313-3323. doi: 10.1007/s00213-022-06216-3. Epub 2022 Sep 12. PMID: 36094619; PMCID: PMC9481488.

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Angelescu I, Kaar SJ, Marques TR, et al. The effect of AUT00206, a Kv3 potassium channel modulator, on dopamine synthesis capacity and the reliability of [18F]-FDOPA imaging in schizophrenia. Journal of Psychopharmacology. 2022;36(9):1061-1069. doi:10.1177/02698811221122031

AUT00206, a Novel Kv3.1/3.2 Positive Modulator, Normalizes Gamma Oscillations in Patients with Schizophrenia
SIRS Pharma Pipeline, April 2022

Ben Mabrouk et al

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AUT00206, a Novel Kv3.1/3.2 Positive Modulator, Normalizes Gamma Oscillations in Patients with Schizophrenia
SIRS Pharma Pipeline, April 2022

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AUT00206, a Novel Kv3.1/3.2 Positive Modulator, Normalizes Gamma Oscillations in Patients with Schizophrenia
Schizophrenia International Research Society (SIRS) meeting, 2022
Large et al

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AUT00206, a Novel Treatment for Schizophrenia, Improves Auditory Mismatch Negativity and Hearing Performance in Patients
SIRS, April 2021

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AUT00206, a Novel Treatment for Schizophrenia, Improves Auditory Mismatch Negativity and Hearing Performance in Patients
SIRS, 2021
Kaar et al

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Improvement in Otoacoustic Emissions and Speech-in-Noise Performance Among Patients with Schizophrenia treated with AUT00206
ARO, 2021
Sanchez et al

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AUT00206, a novel Kv3 channel modulator, reduces ketamine-induced BOLD signalling in healthy male volunteers: a randomised placebo-controlled crossover trial
SIRS, 2019
Deakin et al

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Early clinical evaluation of AUT00206, a novel and selective Kv3 channel modulator for the treatment of schizophrenia.
ACNP, 2016
Hutchison et al

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In vitro evaluation of AUT00206, a novel and selective Kv3 channel modulator for the treatment of schizophrenia
ACNP, 2016
Hutchison et al

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Early clinical evaluation of AUT00206, a novel and selective Kv3 channel modulator for the treatment of schizophrenia
ACNP, 2016

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AUT00206 restores cognitive function in an animal model in 2 tasks in the presence of antipsychotic drugs.
ACNP, 2016
Neill et al

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A novel Kv3 positive modulator augments gamma frequency oscillations in the mammalian neocortex in vitro
4th Biennial Schizophrenia International Research Conference (5-9 April 2014)
Ben Mabrouk et al

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Efficacy and relevance of the modulation of Kv3 channels to alleviate cognitive dysfunction in an animal model of schizophrenia symptomatology
4th Biennial Schizophrenia International Research Conference (5-9 April 2014)
Harte et al

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Two novel KV3 ion channel modulators alleviate cognitive dysfunction and social behaviour deficits of relevance to schizophrenia in an animal model
4th Biennial Schizophrenia International Research Conference (5-9 April 2014)
Leger et al

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Pharmacological activators and inhibitors of Kv3.1 potassium currents
Society for Neuroscience Annual Meeting (9-13 November 2013)
Brown et al

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A novel Kv3 ion channel modulator restores cognitive function in an animal model of cognitive impairment in schizophrenia
European College of Neuropsychopharmacology conference (18 October 2013)
Neill et al

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Pharmacological activators and inhibitors of Kv3.1 potassium currents
ARO Annual Meeting (16-20 February 2013)
Brown et al

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Potential anti-manic efficacy of a Kv3 channel modulator in a model of amphetamine-induced hyperactivity and in CLOCKΔ19 mutant mice
Society for Neuroscience Annual Meeting (13-17 October 2012)
Sidor et al

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Pharmacological modulation of Kv3 potassium channels regulates the firing of parvalbumin-positive cortical interneurons
Society for Neuroscience Annual Meeting (13-17 October 2012)
Large et al

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Pharmacological modulation of Kv3.1 potassium currents
Society for Neuroscience Annual Meeting (13-17 October 2012)
Brown et al

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